Stark L-Ergothioneine 25 mg — an antioxidant amino acid in a dose used in clinical studies

L-ergothioneine is a sulfur-containing amino acid that the body does not synthesize on its own, but obtains with food, mainly from mushrooms. Unlike classic antioxidants, there is a separate transporter for ergothioneine in the body, OCTN1: cells actively capture this compound and accumulate it in tissues with a high oxidative load - in particular, in mitochondria, erythrocytes, liver and skin. Ergothioneine is resistant to autooxidation and is stored in tissues for weeks, which is why it is discussed in the scientific literature as a candidate for the role of the “longevity vitamin”.

Briefly about the product:

• 25 mg of L-ergothioneine in 1 tablet — a dose consistent with most clinical studies
• 60 tablets — 60 daily servings (2 months of use)
• tablet form with clear dosage
• suitable for daily use

What the research showed: skin

In a randomized, double-blind, placebo-controlled trial (Hanayama et al., 2024, Frontiers in Medicine), 80 healthy women were given 25 mg of ergothioneine daily for 12 weeks. The ergothioneine group showed significantly higher skin hydration compared to placebo at week 8, as well as better scores on VISIA wrinkle, texture, UV spots, and pores. Preliminary data from another placebo-controlled trial (30 mg/day, 8 weeks) suggest improved elasticity and reduced wrinkles and age spots.

The mechanism discussed by researchers: ergothioneine accumulates in the skin and in experimental models protects keratinocytes from oxidative damage caused by UV radiation.

What the research showed: memory, sleep and healthy aging

In a randomized, placebo-controlled trial by the Australian research agency CSIRO (Zajac et al., 2025, Nutraceuticals), 147 adults aged 55–79 years with memory complaints took 10 or 25 mg of ergothioneine daily for 16 weeks. It was at the 25 mg dose that statistically significant improvements in subjective prospective memory and sleep were recorded; plasma ergothioneine levels increased 6–16-fold, and the intake was safe and well tolerated.

In a one-year pilot study in Singapore (Yau et al., 2024), in people aged 60+ with mild cognitive impairment, taking 25 mg of ergothioneine three times a week was associated with improved learning performance and stabilization of neurofilament light chain levels, a marker of neuronal damage, which increased in the placebo group over a year. This is a small study (19 participants) and its results need to be confirmed in larger studies.

Observational data complement the picture: in adults 50+, higher plasma ergothioneine levels were associated with better results on memory and executive function tests, while in people with cognitive impairment and dementia, blood ergothioneine levels are on average reduced.

Safety and dosage in studies

In clinical studies, doses of 25–30 mg per day for 4–16 weeks were well tolerated, with no reported side effects; in a one-year study, the intake did not affect blood counts, kidney and liver function. In the EU, ergothioneine is permitted as a food ingredient in amounts up to 30 mg per day for adults. One Stark L-Ergothioneine tablet contains 25 mg - this is the daily dose used in most clinical studies.

Who might be interested?

• for anti-aging skin support "from the inside" - in combination with care
• for people 50+ who want to support cognitive health as part of a healthy lifestyle
• those who rarely eat mushrooms — the main dietary source of ergothioneine
• for those looking for antioxidant support for cells during increased stress

Composition

Composition per 1 tablet: L-ergothioneine — 25 mg.

Excipients: microcrystalline cellulose, lactose, calcium stearate, colloidal silicon dioxide (aerosil).

Recommendations for use: can be recommended as a dietary supplement to the diet as an additional source of L-ergothioneine.

How to use: 1 tablet once a day, washed down with water.

Duration of use: 8 weeks, the course can be repeated if necessary.

Contraindications: individual hypersensitivity to the components. Not recommended for pregnant and lactating women. Not for children under 18 years of age.

Warning: Consult a physician before use. Dietary supplement should not be used as a substitute for a balanced diet. Keep out of reach of children. Do not exceed recommended daily intake.

Release form: tablets.

Packaging: polymer jars of 60 tablets.

Storage conditions: in a dry place, protected from sunlight, at a temperature of 5 °C to 25 °C and a relative humidity of no more than 75%. After opening, keep the package tightly closed.

Shelf life: 24 months from date of manufacture.

It is not a medicine.

You can buy Stark L-Ergothioneine 25 mg 60 tablets Stark Pharm in Kyiv and Ukraine on the websites of our partners and dealers. For current addresses of representatives, stores and online stores, see the section " Where to buy? ".

Stark L-Ergothioneine 25 mg 60 tablets (antioxidant, anti-aging amino acid)