Stark Fisetin β-Cyclodextrin Matrix 100 mg, senolytic, anti-aging 60 capsules

Fisetin with beta-cyclodextrin Stark Fisetin β-Cyclodextrin Matrix 100 mg, senolytic, anti-aging

Supplement Stark Fisetin β-Cyclodextrin Matrix from Stark Pharm contains fisetin, a powerful natural flavonoid, combined with β-Cyclodextrin to significantly increase its bioavailability. This formula is designed to support cognitive function and healthy aging.

1. Fisetin: an active senolytic and neuroprotective component

Fisetin is a polyphenolic compound of the flavonol class that has attracted scientific attention due to its unique biological properties, which have been investigated in vitro (in a test tube) and in vivo (in animals), as well as in initial human clinical trials.

A. Senolytic activity (anti-aging)

• Mechanism of action: fisetin is recognized as one of the few known natural senolytic agents [1.2]. Senolytics selectively induce apoptosis (programmed cell death) of senescent cells . These cells accumulate with age, secreting pro-inflammatory substances (SASP) and contributing to chronic inflammation and tissue dysfunction [1.2, 1.3];

• Research: a study published in EBioMedicine (2018) showed that fisetin reduced the number of senescent cells in aged mice, leading to an increase in median and maximum lifespan and improved health indices [1.2];

• Initial clinical data: pilot clinical studies are currently underway to examine the effects of fisetin on biological age and other markers of aging in healthy adults, supporting its potential as a therapeutic agent to combat age-related diseases [1.1].

B. Neuroprotective and cognitive effects

• Crossing the blood-brain barrier: fisetin is a lipophilic compound that is able to penetrate the blood-brain barrier, allowing it to directly affect neurons [2.1];

• Supporting cognition: research suggests that fisetin may stimulate signaling pathways associated with long-term memory and support synaptic function in the aging brain [2.3];

• Antioxidant protection: fisetin acts as a powerful antioxidant, helping to maintain glutathione levels (a key cellular antioxidant) and mitochondrial function, protecting nerve cells from oxidative stress [2.2, 2.3].

2. β-Cyclodextrin Technology for Bioavailability

On its own, fisetin has a very low solubility in water (<1 mg/mL) and is therefore poorly absorbed from the gastrointestinal tract [3.1, 3.3]. To overcome this limitation, a β -cyclodextrin matrix is used.

• Mechanism: beta-cyclodextrin ( β -CD) is a cyclic oligosaccharide that forms an inclusion complex with fisetin. Fisetin is located in the internal hydrophobic cavity of β -CD [3.1];

• Effect: complex formation significantly increases the solubility of fisetin in the body's aqueous environment [3.2]. This is key to increasing systemic bioavailability and ensuring that the active ingredient is effectively absorbed after oral administration [3.3].

List of scientific sources used:

1. Senolytic Activity (Fisetin as a senolytic)

1.1. You, Y. et al. (2024). Effects of a Fisetin Supplement on Biological Age and Other Health Markers in Healthy Adults: A Pilot Study. Alternative Therapies In Health And Medicine, 30(2), 160–167.

1.2. Yousefzadeh, MJ et al. (2018). Fisetin is a senotherapeutic that extends health span and lifespan. EBioMedicine, 28, 209–218.

1.3. Lu, S. et al. (2024). Current perspectives on the potential therapeutic applications of fisetin: a comprehensive review of preclinical and clinical studies. Phytotherapy Research.

2. Neuroprotection and cognitive function

2.1. Maher, P. (2017). Fisetin: a review of its neuroprotective effects on traumatic brain injury, stroke, and age-related neurodegeneration. European Journal of Neuroscience, 45(2), 178-185.

2.2. Ahmad, A. et al. (2017). Fisetin mitigates mitochondrial- and oxidative stress-associated neuroinflammation in a rat model of intracerebral hemorrhage. Journal of Neuroimmunology, 309, 1-9.

2.3. Currais, A. et al. (2014). Modulation of multiple molecular targets by fisetin maintains synaptic function during cerebral aging. Aging Cell, 13(2), 299-307.

3. β-Cyclodextrin Technology (Enhancing bioavailability)

3.1. Guzzo, MG et al. (2007). Study of the Complexation of Fisetin with Cyclodextrins. Journal of Physical Chemistry B, 111(38), 11303–11310.

3.2. Muguruma, H. (2021). Fisetin/Cyclodextrin Complex Formation for Enhanced Bioavailability of the Flavonoid. Molecules, 26(15), 4467.

3.3. Pielesz, G. et al. (2023). Cyclodextrins for the Delivery of Bioactive Compounds from Natural Sources: Medicinal, Food and Cosmetics Applications. International Journal of Molecular Sciences, 24(3), 2728.

Please note that the studies listed are examples of the scientific evidence that supports the potential benefits of fisetin. It is recommended that you consult your doctor before taking any dietary supplements. The information is provided for informational purposes only and should not be considered medical advice.

One capsule contains:

• Fisetin (98% extract from the stems of the common cotinus tree (Cotinus coggygria Scop.)) - 100 mg

Additional components:

• β-cyclodextrin
• Microcrystalline cellulose
• Magnesium stearate
• Hydroxypropylmethylcellulose capsule (vegetable)

The formula contains fisetin complexed with β-cyclodextrin for improved solubility.

Recommendations for use:

Use as directed or as recommended by a specialist/doctor.

Method of use:

The recommended daily dose is 1 capsule. Take 1 capsule once a day. Take regardless of meals, with water.

Duration of use: 4-8 weeks, if necessary, the course can be repeated after 4 weeks.

Caution: do not exceed recommended dosage. Consult a doctor if you have any medical conditions, are taking medications, or are pregnant or lactating.

The product is not a substitute for a varied and balanced diet. Use only as a supplement to a complete diet.

Contraindications: individual hypersensitivity to the components.

Release form: capsules.

Packaging: polymer jars of 60 capsules.

Shelf life: 24 months from the date of manufacture (see the label (packaging) for the date of manufacture or "Use by" date).

Storage conditions: in a dry, sun-protected place at a temperature of 5°C to 25°C and a relative humidity of no more than 75%; out of the reach of children.

It is not a medicine.

You can buy Stark Fisetin β-Cyclodextrin Matrix 100 mg, senolytic, anti-aging 60 capsules Stark Pharm in Kyiv and Ukraine on the websites of our partners and dealers, see the addresses of our representatives, stores and online stores in the ''Where to buy?'' section.