Stark Beta-Glucan 500 mg 60 capsules (beta-glucan)

Stark Beta-Glucan 500 mg — support of the protective functions of the immune system every day

Stark Beta-Glucan is a Stark Pharm dietary supplement in capsules with beta-1,3/1,6-D-glucan.

Beta-glucan is a natural polysaccharide that can help support the immune system and the body's natural defense mechanisms.

The composition uses an extract from the cell walls of baker's yeast Saccharomyces cerevisiae with a clear dosage of 500 mg per capsule.

Briefly about the product:

• Beta-1,3/1,6-D-glucan — 500 mg in 1 capsule.
• Source: extract from the cell walls of baker's yeast Saccharomyces cerevisiae.
• Release form: capsules.
• Recommended dosage: 1 capsule per day.
• Packaging: 60 capsules.
• Additional ingredients: microcellulose, gelatin capsule.
• The permissible deviation of the component mass per capsule is ±10%.

How it works:

• Immune support: May help support the body's natural immune response.
• Protective functions: may help maintain general protective mechanisms in the daily rhythm.
• Cellular link: may help maintain the functional activity of immune cells.
• Adaptation: may be appropriate during periods of increased workload and stress.
• Seasonality: can support immunity during periods of seasonal change.
• Course convenience: taking 1 capsule per day is easily integrated into your usual regimen.

The effect of Stark Beta-Glucan supplement

• Immunity: May help support immune system function.
• Protection: may help support the body's defenses.
• Resilience: can help maintain the body's resistance to external factors.
• Tone: can help maintain overall well-being in a daily rhythm.
• Recovery: may be appropriate during periods of general fatigue and stress.
• Daily intake: convenient capsule format for regular use.

Scientific data (oral beta-1,3/1,6-glucan from yeast)

A systematic review and meta-analysis of 13 randomized placebo-controlled trials in healthy subjects showed that yeast β-glucans statistically significantly reduced the incidence/risk of URTI episodes (OR = 0.345; 95% CI 0.192–0.620), and also reduced the number of episodes (SMD = −0.315) and duration of cold episodes (SMD = −0.312). The authors also noted that in most of the included studies, β-glucan improved symptom severity , and the supplement was generally well tolerated .

In a placebo-controlled study in marathon runners, Wellmune WGP® (β-1,3/1,6-glucan from yeast) at a dose of 250 or 500 mg/day for 4 weeks after the race was associated with a lower incidence of URTI symptoms: at week 4, URTI was reported by 8% of participants in the β-glucan groups versus 24% in the placebo group.

Another study after intense exercise showed that β-glucan was associated with a 37% reduction in the number of “cold/flu symptom days” after a marathon (compared to placebo) and a 32% increase in secretory IgA in saliva 2 hours after exercise, a marker of mucosal immune defense of the respiratory tract.

In the RCT with a beverage containing dispersed yeast β-glucan, fewer symptomatic days (3.43 ± 6.44 vs. 3.84 ± 6.84) and lower total symptom severity (4.52 ± 1.61 vs. 5.60 ± 2.23) were reported in the per-protocol analysis, as well as fewer missed training days due to URTI after a marathon (0.09 ± 0.38 vs. 0.36 ± 1.40).

Publications (primary sources):
[1] https://link.springer.com/article/10.1007/s00394-021-02566-4
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC3761532/
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC5044766/
[4] https://pubmed.ncbi.nlm.nih.gov/30380356/

Mechanism of action of β-1,3/1,6-glucan

β-1,3/1,6-glucan from the yeast cell wall is considered a molecular “signal” (MAMP) that is recognized by innate immune receptors on defense cells. Dectin-1 is considered a key receptor (on macrophages, neutrophils, dendritic cells), and interaction/cooperation with CR3 and other PRRs is described - this can trigger intracellular signaling cascades (in particular via Syk/CARD9 → NF-κB) and maintain the “readiness” of cells to respond to microbial stimuli. [1–3]

What happens when ingested: Some of the β-glucan particles pass into the upper small intestine, where they can be taken up by cells of the intestinal immune system (macrophages/dendritic cells). The β-glucan is then phagocytized and processed , and the smaller soluble fragments can then be transported to immune organs (e.g., spleen) where they prime other innate immune cells—one of the most common mechanistic scenarios for the systemic effects of oral ingestion. [1,4]

“Trained immunity”: In modern reviews, β-glucans are described as one of the classic triggers of a longer-term functional reprogramming of innate immune cells (mainly monocytes/macrophages) — after a “first contact”, the cells can respond faster/more effectively to repeated stimuli. This effect is associated with receptor pathways (in particular Dectin-1) and intracellular changes in response regulation. [1–2,5]

Summary for practice: β-1,3/1,6-glucan works not as a “vitamin,” but as a component that can gently modulate the activity of innate immunity — especially important during periods of stress, seasonal changes, and stress.

Publications (primary sources):
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC7816268/
[2] https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.812148/full
[3] https://link.springer.com/article/10.1186/1475-2891-13-38
[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC4567044/
[5] https://www.mdpi.com/2304-8158/12/3/659

Benefits of the formula

• Beta-1,3/1,6-glucan: the specified form of the active ingredient in the composition.
• 500 mg per capsule: clear dosage for daily intake.
• Yeast source: Saccharomyces cerevisiae cell wall extract.
• Laconic composition: active ingredient + microcellulose + gelatin capsule.

Who might be interested?

• For those who want to add beta-glucan to their diet as a component to support immunity.
• During periods of seasonal changes, increased workload or stress.
• For people with an active lifestyle who are looking for daily nutritional support for protective functions.

Composition

Composition per 1 capsule: beta-1,3/1,6-D-glucan (extract from the cell walls of baker's yeast Saccharomyces cerevisiae) - 500 mg.

Excipients: microcellulose, gelatin capsule.

Recommendations for use: can be recommended as a dietary supplement to increase the protective functions of the body's immune system.

Directions: Take 1 capsule per day, 30 minutes before meals, with a glass of water.

Contraindications: individual intolerance to the product components, children, pregnant women and during lactation.

Caution: Do not exceed the recommended daily amount. The permissible deviation in the mass of the component per capsule is ±10%.

Release form: capsules.

Packaging: polymer jars of 60 capsules.

Storage conditions: in a dry, sun-protected place at a temperature of 5°C to 25°C and a relative humidity of no more than 75%; out of the reach of children.

Shelf life: 24 months from date of manufacture.

It is not a medicine.

You can buy Stark Beta-Glucan 500 mg 60 capsules Stark Pharm in Kyiv and Ukraine on the websites of our partners and dealers. For current addresses of representatives, stores and online stores, see the section "Where to buy?".